Growth arrest-specific protein 7 (GAS7)

About Growth arrest-specific protein 7

Growth arrest-specific protein 7 (GAS7) is a protein from Homo sapiens identified by UniProt accession O60861, 476 residues long. MolForge cross-references it against 0 known binders and 253 disease associations.

Target properties

Protein name	Growth arrest-specific protein 7
UniProt accession	O60861
Gene	GAS7
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (253)

Diseases linked to this target (Open Targets).

intraocular pressure measurement · score 0.51
open-angle glaucoma · score 0.49
glaucoma · score 0.48
heel bone mineral density · score 0.43
body height · score 0.42
Antiglaucoma preparations and miotics use measurement · score 0.35
sitting height measurement · score 0.32
visual perception measurement · score 0.32
cortical thickness · score 0.31
blood phosphate measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60861-F1	alphafold	PREDICTED	83.74	—

Amino-acid sequence (476 residues)

MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG WFPASYVQLL EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards