Endothelial differentiation-related factor 1 (EDF1)

About Endothelial differentiation-related factor 1

Endothelial differentiation-related factor 1 (EDF1) is a protein from Homo sapiens identified by UniProt accession O60869, 148 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Endothelial differentiation-related factor 1
UniProt accession	O60869
Gene	EDF1
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
cyst · score 0.03
Abnormal sperm morphology · score 0.02
PHF-tau measurement · score 0.02
lymphocyte:monocyte ratio · score 0.02
platelet component distribution width · score 0.02
systemic juvenile idiopathic arthritis · score 0.02
infect · score 0.01
infection · score 0.01
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60869-F1	alphafold	PREDICTED	83.59	—

Amino-acid sequence (148 residues)

MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN EKPQVIADYE SGRAIPNNQV LGKIERAIGL KLRGKDIGKP IEKGPRAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards