DNA/RNA-binding protein KIN17 (KIN)

About DNA/RNA-binding protein KIN17

DNA/RNA-binding protein KIN17 (KIN) is a protein from Homo sapiens identified by UniProt accession O60870, 393 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.

Target properties

Protein name	DNA/RNA-binding protein KIN17
UniProt accession	O60870
Gene	KIN
Organism	Homo sapiens
Length	393 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (172)

Diseases linked to this target (Open Targets).

lysosomal storage disease · score 0.27
Parkinson disease · score 0.27
multiple sclerosis · score 0.27
neurodegenerative disease · score 0.27
Alzheimer disease · score 0.27
erythrocyte count · score 0.17
mean reticulocyte volume · score 0.11
breast cancer · score 0.09
Familial short QT syndrome · score 0.08
Brugada syndrome · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60870-F1	alphafold	PREDICTED	77.77	—

Amino-acid sequence (393 residues)

MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH QRQLLLASEN PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS HREHIHMNAT QWETLTDFTK WLGREGLCKV DETPKGWYIQ YIDRDPETIR RQLELEKKKK QDLDDEEKTA KFIEEQVRRG LEGKEQEVPT FTELSRENDE EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK RKESSQSSTQ SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY RGNEGTLESI NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards