About SH2 domain-containing protein 1A
SH2 domain-containing protein 1A (SH2D1A) is a protein
from Homo sapiens identified by UniProt accession
O60880, 128 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | SH2 domain-containing protein 1A |
|---|
| UniProt accession | O60880 |
|---|
| Gene | SH2D1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 128 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (281)
Diseases linked to this target (Open Targets).
- X-linked lymphoproliferative disease · score 0.79
- X-linked lymphoproliferative syndrome · score 0.52
- lymphoma · score 0.46
- genetic disorder · score 0.38
- autoinflammatory syndrome · score 0.37
- neurodegenerative disease · score 0.24
- lymphoproliferative syndrome · score 0.13
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.09
- Hodgkins lymphoma · score 0.09
- combined immunodeficiency with skin granulomas · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60880-F1 | alphafold | PREDICTED | 83.71 | — |
Amino-acid sequence (128 residues)
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
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