Matrix metalloproteinase-20 (MMP20)

About Matrix metalloproteinase-20

Matrix metalloproteinase-20 (MMP20) is a protein from Homo sapiens identified by UniProt accession O60882, 483 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	Matrix metalloproteinase-20
UniProt accession	O60882
Gene	MMP20
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

Hypomaturation amelogenesis imperfecta · score 0.71
amelogenesis imperfecta · score 0.54
mean platelet volume · score 0.43
recessive amelogenesis imperfecta · score 0.41
neuroinflammatory disorder · score 0.36
matrix metalloproteinase 7 measurement · score 0.31
urinary metabolite measurement · score 0.31
neuroblastoma · score 0.30
alcohol consumption measurement · score 0.27
wellbeing measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60882-F1	alphafold	PREDICTED	83.28	—

Amino-acid sequence (483 residues)

MKVLPASGLA VFLIMALKFS TAAPSLVAAS PRTWRNNYRL AQAYLDKYYT NKEGHQIGEM VARGSNSMIR KIKELQAFFG LQVTGKLDQT TMNVIKKPRC GVPDVANYRL FPGEPKWKKN TLTYRISKYT PSMSSVEVDK AVEMALQAWS SAVPLSFVRI NSGEADIMIS FENGDHGDSY PFDGPRGTLA HAFAPGEGLG GDTHFDNAEK WTMGTNGFNL FTVAAHEFGH ALGLAHSTDP SALMYPTYKY KNPYGFHLPK DDVKGIQALY GPRKVFLGKP TLPHAPHHKP SIPDLCDSSS SFDAVTMLGK ELLLFKDRIF WRRQVHLRTG IRPSTITSSF PQLMSNVDAA YEVAERGTAY FFKGPHYWIT RGFQMQGPPR TIYDFGFPRH VQQIDAAVYL REPQKTLFFV GDEYYSYDER KRKMEKDYPK NTEEEFSGVN GQIDAAVELN GYIYFFSGPK TYKYDTEKED VVSVVKSSSW IGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards