G-protein coupled receptor 37-like 1 (GPR37L1)

About G-protein coupled receptor 37-like 1

G-protein coupled receptor 37-like 1 (GPR37L1) is a protein from Homo sapiens identified by UniProt accession O60883, 481 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	G-protein coupled receptor 37-like 1
UniProt accession	O60883
Gene	GPR37L1
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.26
ovarian cancer · score 0.25
glioblastoma multiforme · score 0.25
age at first sexual intercourse measurement · score 0.22
head and neck squamous cell carcinoma · score 0.16
prostate adenocarcinoma · score 0.10
pseudotumor cerebri · score 0.05
metabolic syndrome X · score 0.05
Supravalvular aortic stenosis · score 0.05
supravalvular aortic stenosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60883-F1	alphafold	PREDICTED	67.77	—

Amino-acid sequence (481 residues)

MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards