DnaJ homolog subfamily A member 2 (DNAJA2)

About DnaJ homolog subfamily A member 2

DnaJ homolog subfamily A member 2 (DNAJA2) is a protein from Homo sapiens identified by UniProt accession O60884, 412 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	DnaJ homolog subfamily A member 2
UniProt accession	O60884
Gene	DNAJA2
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

response to simvastatin · score 0.17
total cholesterol change measurement · score 0.17
response to fenofibrate · score 0.17
Female infertility due to fertilization defect · score 0.07
neoplasm · score 0.06
female infertility due to oocyte meiotic arrest · score 0.06
Red cell distribution width · score 0.06
Hydatidiform Mole · score 0.05
cancer · score 0.05
premature ovarian failure 19 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60884-F1	alphafold	PREDICTED	83.37	—

Amino-acid sequence (412 residues)

MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE LEDLLPSRPE VPNIIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS SHHGPGVQCA HQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards