Receptor activity-modifying protein 1 (RAMP1)

About Receptor activity-modifying protein 1

Receptor activity-modifying protein 1 (RAMP1) is a protein from Homo sapiens identified by UniProt accession O60894, 148 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Receptor activity-modifying protein 1
UniProt accession	O60894
Gene	RAMP1
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.54
adolescent idiopathic scoliosis · score 0.29
COVID-19 · score 0.08
obesity · score 0.07
neoplasm · score 0.06
Pneumonia · score 0.05
Hepatitis · score 0.04
familial cylindromatosis · score 0.04
Moyamoya disease · score 0.04
pseudotumor cerebri · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60894-F1	alphafold	PREDICTED	89.73	—

Amino-acid sequence (148 residues)

MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA VGETLWCDWG RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY FRSCPISGRA VRDPPGSILY PFIVVPITVT LLVTALVVWQ SKRTEGIV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards