Receptor activity-modifying protein 2 (RAMP2)

About Receptor activity-modifying protein 2

Receptor activity-modifying protein 2 (RAMP2) is a protein from Homo sapiens identified by UniProt accession O60895, 175 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Receptor activity-modifying protein 2
UniProt accession	O60895
Gene	RAMP2
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.24
type 2 diabetes mellitus · score 0.17
neoplasm · score 0.08
cancer · score 0.06
body height · score 0.06
waist-hip ratio · score 0.06
chondrosarcoma · score 0.05
lung adenocarcinoma · score 0.05
pulse pressure measurement · score 0.04
Stroke · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60895-F1	alphafold	PREDICTED	80.92	—

Amino-acid sequence (175 residues)

MASLRVERAG GPRLPRTRVG RPAALRLLLL LGAVLNPHEA LAQPLPTTGT PGSEGGTVKN YETAVQFCWN HYKDQMDPIE KDWCDWAMIS RPYSTLRDCL EHFAELFDLG FPNPLAERII FETHQIHFAN CSLVQPTFSD PPEDVLLAMI IAPICLIPFL ITLVVWRSKD SEAQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards