Receptor activity-modifying protein 3 (RAMP3)

About Receptor activity-modifying protein 3

Receptor activity-modifying protein 3 (RAMP3) is a protein from Homo sapiens identified by UniProt accession O60896, 148 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Receptor activity-modifying protein 3
UniProt accession	O60896
Gene	RAMP3
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
neuroinflammatory disorder · score 0.27
glioblastoma multiforme · score 0.18
neoplasm · score 0.06
adolescent idiopathic scoliosis · score 0.05
hepatocellular carcinoma · score 0.05
metabolite measurement · score 0.05
Pneumonia · score 0.04
cancer · score 0.03
ulcerative colitis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60896-F1	alphafold	PREDICTED	87.57	—

Amino-acid sequence (148 residues)

METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards