Short stature homeobox protein 2 (SHOX2)

About Short stature homeobox protein 2

Short stature homeobox protein 2 (SHOX2) is a protein from Homo sapiens identified by UniProt accession O60902, 331 residues long. MolForge cross-references it against 0 known binders and 276 disease associations.

Target properties

Protein name	Short stature homeobox protein 2
UniProt accession	O60902
Gene	SHOX2
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (276)

Diseases linked to this target (Open Targets).

body height · score 0.38
body fat percentage · score 0.26
appendicular lean mass · score 0.26
body mass index · score 0.23
pulse pressure measurement · score 0.21
vital capacity · score 0.18
smoking status measurement · score 0.18
systolic blood pressure · score 0.17
unipolar depression · score 0.17
depressive symptom measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60902-F1	alphafold	PREDICTED	59.81	—

Amino-acid sequence (331 residues)

MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP TGCTEAGRDD RSSPAVRAAG GGGGGGGGGG GGGGGGGVGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEVSPEL KDRKEDAKGM EDEGQTKIKQ RRSRTNFTLE QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV AAAAAAKTTS KNSSIADLRL KAKKHAAALG L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards