Beta-1,4-galactosyltransferase 2 (B4GALT2)

About Beta-1,4-galactosyltransferase 2

Beta-1,4-galactosyltransferase 2 (B4GALT2) is a protein from Homo sapiens identified by UniProt accession O60909, 372 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Beta-1,4-galactosyltransferase 2
UniProt accession	O60909
Gene	B4GALT2
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
lysosomal storage disease · score 0.46
Alzheimer disease · score 0.46
Parkinson disease · score 0.46
multiple sclerosis · score 0.46
blood protein measurement · score 0.22
IGF-1 measurement · score 0.16
self reported educational attainment · score 0.05
intelligence · score 0.05
age at first birth measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60909-F1	alphafold	PREDICTED	86.75	—

Amino-acid sequence (372 residues)

MSRLLGGTLE RVCKAVLLLC LLHFLVAVIL YFDVYAQHLA FFSRFSARGP AHALHPAASS SSSSSNCSRP NATASSSGLP EVPSALPGPT APTLPPCPDS PPGLVGRLLI EFTSPMPLER VQRENPGVLM GGRYTPPDCT PAQTVAVIIP FRHREHHLRY WLHYLHPILR RQRLRYGVYV INQHGEDTFN RAKLLNVGFL EALKEDAAYD CFIFSDVDLV PMDDRNLYRC GDQPRHFAIA MDKFGFRLPY AGYFGGVSGL SKAQFLRING FPNEYWGWGG EDDDIFNRIS LTGMKISRPD IRIGRYRMIK HDRDKHNEPN PQRFTKIQNT KLTMKRDGIG SVRYQVLEVS RQPLFTNITV DIGRPPSWPP RG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards