Cathepsin L2 (CTSV)

About Cathepsin L2

Cathepsin L2 (CTSV) is a protein from Homo sapiens identified by UniProt accession O60911, 334 residues long. MolForge cross-references it against 0 known binders and 521 disease associations.

Target properties

Protein name	Cathepsin L2
UniProt accession	O60911
Gene	CTSV
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (521)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
adolescent idiopathic scoliosis · score 0.29
blood protein measurement · score 0.29
breast adenocarcinoma · score 0.25
lung adenocarcinoma · score 0.19
cutaneous melanoma · score 0.15
Alopecia-intellectual disability syndrome · score 0.11
Alopecia universalis · score 0.10
glioblastoma multiforme · score 0.10
hypotrichosis simplex · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60911-F1	alphafold	PREDICTED	92.93	—

Amino-acid sequence (334 residues)

MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards