Prefoldin subunit 1 (PFDN1)

About Prefoldin subunit 1

Prefoldin subunit 1 (PFDN1) is a protein from Homo sapiens identified by UniProt accession O60925, 122 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	Prefoldin subunit 1
UniProt accession	O60925
Gene	PFDN1
Organism	Homo sapiens
Length	122 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
endometrial cancer · score 0.23
reaction time measurement · score 0.22
mathematical ability · score 0.18
intelligence · score 0.16
cognitive function measurement · score 0.16
worry measurement · score 0.14
verbal-numerical reasoning measurement · score 0.13
bilirubin measurement · score 0.12
balding measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60925-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (122 residues)

MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE IMTLVDETNM YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR AQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards