E3 ubiquitin-protein ligase PPP1R11 (PPP1R11)

About E3 ubiquitin-protein ligase PPP1R11

E3 ubiquitin-protein ligase PPP1R11 (PPP1R11) is a protein from Homo sapiens identified by UniProt accession O60927, 126 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase PPP1R11
UniProt accession	O60927
Gene	PPP1R11
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
HIV-1 infection · score 0.04
asthma · score 0.03
lipid measurement · score 0.03
late-onset myasthenia gravis · score 0.03
Takayasu arteritis · score 0.02
drug-induced liver injury · score 0.02
Varicose veins · score 0.02
colorectal carcinoma · score 0.01
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60927-F1	alphafold	PREDICTED	65.91	—

Amino-acid sequence (126 residues)

MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP PGPMQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards