Inward rectifier potassium channel 13 (KCNJ13)

About Inward rectifier potassium channel 13

Inward rectifier potassium channel 13 (KCNJ13) is a protein from Homo sapiens identified by UniProt accession O60928, 360 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Inward rectifier potassium channel 13
UniProt accession	O60928
Gene	KCNJ13
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

Leber congenital amaurosis 16 · score 0.71
snowflake vitreoretinal degeneration · score 0.54
Leber congenital amaurosis · score 0.52
coronary artery disease · score 0.22
body height · score 0.22
lean body mass · score 0.19
schizophrenia · score 0.17
appendicular lean mass · score 0.16
fat body mass · score 0.16
Nasal Cavity Polyp · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60928-F1	alphafold	PREDICTED	82.97	—

Amino-acid sequence (360 residues)

MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD MRWRWMMLVF SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV KYITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDTAVVAH MDGKPNLIFQ VANTRPSPLT SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP LTYYHSITPS SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN FQISETGLTE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards