Ribonuclease H1 (RNASEH1)

About Ribonuclease H1

Ribonuclease H1 (RNASEH1) is a protein from Homo sapiens identified by UniProt accession O60930, 286 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Ribonuclease H1
UniProt accession	O60930
Gene	RNASEH1
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 · score 0.73
adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy · score 0.37
genetic disorder · score 0.19
viral disease · score 0.04
mitochondrial disease · score 0.03
Barth syndrome · score 0.03
Atypical Lipomatous Tumor · score 0.02
progressive external ophthalmoplegia · score 0.02
cancer · score 0.02
dengue disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60930-F1	alphafold	PREDICTED	79.55	—

Amino-acid sequence (286 residues)

MSWLLFLAHR VALAALPCRR GSRGFGMFYA VRRGRKTGVF LTWNECRAQV DRFPAARFKK FATEDEAWAF VRKSASPEVS EGHENQHGQE SEAKASKRLR EPLDGDGHES AEPYAKHMKP SVEPAPPVSR DTFSYMGDFV VVYTDGCCSS NGRRRPRAGI GVYWGPGHPL NVGIRLPGRQ TNQRAEIHAA CKAIEQAKTQ NINKLVLYTD SMFTINGITN WVQGWKKNGW KTSAGKEVIN KEDFVALERL TQGMDIQWMH VPGHSGFIGN EEADRLAREG AKQSED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards