Cystinosin (CTNS)

About Cystinosin

Cystinosin (CTNS) is a protein from Homo sapiens identified by UniProt accession O60931, 367 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Cystinosin
UniProt accession	O60931
Gene	CTNS
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

nephropathic cystinosis · score 0.85
Juvenile nephropathic cystinosis · score 0.77
ocular cystinosis · score 0.77
juvenile nephropathic cystinosis · score 0.74
cystinosis · score 0.67
genetic disorder · score 0.56
nephropathic infantile cystinosis · score 0.55
neurodegenerative disease · score 0.27
nephrotic syndrome · score 0.26
neuroinflammatory disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60931-F1	alphafold	PREDICTED	89.41	—

Amino-acid sequence (367 residues)

MIRNWLTIFI LFPLKLVEKC ESSVSLTVPP VVKLENGSST NVSLTLRPPL NATLVITFEI TFRSKNITIL ELPDEVVVPP GVTNSSFQVT SQNVGQLTVY LHGNHSNQTG PRIRFLVIRS SAISIINQVI GWIYFVAWSI SFYPQVIMNW RRKSVIGLSF DFVALNLTGF VAYSVFNIGL LWVPYIKEQF LLKYPNGVNP VNSNDVFFSL HAVVLTLIII VQCCLYERGG QRVSWPAIGF LVLAWLFAFV TMIVAAVGVT TWLQFLFCFS YIKLAVTLVK YFPQAYMNFY YKSTEGWSIG NVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FSIVFDVVFF IQHFCLYRKR PGYDQLN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards