About Dystrobrevin beta
Dystrobrevin beta (DTNB) is a protein
from Homo sapiens identified by UniProt accession
O60941, 627 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Dystrobrevin beta |
|---|
| UniProt accession | O60941 |
|---|
| Gene | DTNB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 627 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.31
- reticulocyte measurement · score 0.30
- cutaneous melanoma · score 0.30
- erythrocyte count · score 0.28
- nevus count · score 0.24
- multiple myeloma · score 0.20
- insulin like growth factor measurement · score 0.20
- type 2 diabetes mellitus · score 0.20
- heel bone mineral density · score 0.19
- triglyceride measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60941-F1 | alphafold | PREDICTED | 75.35 | — |
Amino-acid sequence (627 residues)
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS SLVKELHSAE EGAEEEEEKM QNGKDRG
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