About Leukocyte immunoglobulin-like receptor subfamily B member 3
Leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) is a protein
from Homo sapiens identified by UniProt accession
O75022, 631 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Leukocyte immunoglobulin-like receptor subfamily B member 3 |
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| UniProt accession | O75022 |
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| Gene | LILRB3 |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- birth weight · score 0.30
- neurodegenerative disease · score 0.17
- blood protein measurement · score 0.15
- Takayasu arteritis · score 0.10
- alkaline phosphatase measurement · score 0.09
- platelet crit · score 0.06
- common variable immunodeficiency · score 0.06
- Chronic mucocutaneous candidosis · score 0.06
- isolated agammaglobulinemia · score 0.06
- Hodgkins lymphoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75022-F1 | alphafold | PREDICTED | 73.99 | — |
Amino-acid sequence (631 residues)
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSQEAQEYRL HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY YSSAGWSEPS DPLEMVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL FPVGPVTPSH RWRFTCYYYY TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPHLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA VTYAPVKHSS PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS LTLRRKATEP PPSQEGEPPA EPSIYATLAI H
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