About Leukocyte immunoglobulin-like receptor subfamily B member 5
Leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5) is a protein
from Homo sapiens identified by UniProt accession
O75023, 590 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Leukocyte immunoglobulin-like receptor subfamily B member 5 |
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| UniProt accession | O75023 |
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| Gene | LILRB5 |
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| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (119)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- body height · score 0.36
- creatine kinase measurement · score 0.35
- aspartate aminotransferase measurement · score 0.33
- high density lipoprotein cholesterol measurement · score 0.32
- L lactate dehydrogenase measurement · score 0.31
- appendicular lean mass · score 0.30
- sitting height measurement · score 0.25
- apolipoprotein A 1 measurement · score 0.25
- IGF-1 measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75023-F1 | alphafold | PREDICTED | 75.58 | — |
Amino-acid sequence (590 residues)
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD APAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH
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