About Iron-sulfur clusters transporter ABCB7, mitochondrial
Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) is a protein
from Homo sapiens identified by UniProt accession
O75027, 752 residues long.
MolForge cross-references it against 0 known binders and
191 disease associations.
Target properties
| Protein name | Iron-sulfur clusters transporter ABCB7, mitochondrial |
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| UniProt accession | O75027 |
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| Gene | ABCB7 |
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| Organism | Homo sapiens |
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| Length | 752 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (191)
Diseases linked to this target (Open Targets).
- X-linked sideroblastic anemia with ataxia · score 0.82
- Sideroblastic anemia · score 0.37
- genetic disorder · score 0.33
- spinocerebellar ataxia type 1 · score 0.33
- mitochondrial disease · score 0.19
- vaginal discharge · score 0.11
- myelodysplastic syndrome · score 0.09
- refractory anemia with ringed sideroblasts · score 0.06
- refractory anemia · score 0.04
- cardiac hypertrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75027-F1 | alphafold | PREDICTED | 78.12 | — |
Amino-acid sequence (752 residues)
MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG TARAYQIPES LKSITWQRLG KGNSGQFLDA AKALQVWPLI EKRTCWHGHA GGGLHTDPKE GLKDVDTRKI IKAMLSYVWP KDRPDLRARV AISLGFLGGA KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD APNTVATMAT AVLIGYGVSR AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF HLSRQTGALS KAIDRGTRGI SFVLSALVFN LLPIMFEVML VSGVLYYKCG AQFALVTLGT LGTYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNER YEAQRYDGFL KTYETASLKS TSTLAMLNFG QSAIFSVGLT AIMVLASQGI VAGTLTVGDL VMVNGLLFQL SLPLNFLGTV YRETRQALID MNTLFTLLKV DTQIKDKVMA SPLQITPQTA TVAFDNVHFE YIEGQKVLSG ISFEVPAGKK VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNIQDVS LESLRRAVGV VPQDAVLFHN TIYYNLLYGN ISASPEEVYA VAKLAGLHDA ILRMPHGYDT QVGERGLKLS GGEKQRVAIA RAILKDPPVI LYDEATSSLD SITEETILGA MKDVVKHRTS IFIAHRLSTV VDADEIIVLD QGKVAERGTH HGLLANPHSI YSEMWHTQSS RVQNHDNPKW EAKKENISKE EERKKLQEEI VNSVKGCGNC SC
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