Heat shock factor 2-binding protein (HSF2BP)

About Heat shock factor 2-binding protein

Heat shock factor 2-binding protein (HSF2BP) is a protein from Homo sapiens identified by UniProt accession O75031, 334 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Heat shock factor 2-binding protein
UniProt accession	O75031
Gene	HSF2BP
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

premature ovarian failure 19 · score 0.46
mean corpuscular volume · score 0.36
mean corpuscular hemoglobin · score 0.34
erythrocyte count · score 0.31
systolic blood pressure · score 0.30
diastolic blood pressure · score 0.30
mean corpuscular hemoglobin concentration · score 0.30
cardiovascular disease · score 0.27
hypertension · score 0.27
neurodegenerative disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75031-F1	alphafold	PREDICTED	91.00	—

Amino-acid sequence (334 residues)

MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV LESFQKLKIV EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL ALRQQLNEAK QQLLQQAEYC TEMGAAACTL LWGVSSSEEV VKAILGGDKA LKFFSITGQT MESFVKSLDG DVQELDSDES QFVFALAGIV TNVAAIACGR EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV SINLKGLKYI SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards