About Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP) is a protein
from Homo sapiens identified by UniProt accession
O75052, 506 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
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| UniProt accession | O75052 |
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| Gene | NOS1AP |
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| Organism | Homo sapiens |
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| Length | 506 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (289)
Diseases linked to this target (Open Targets).
- nephrotic syndrome, type 22 · score 0.54
- neurodegenerative disease · score 0.49
- electrocardiography · score 0.46
- QT interval · score 0.43
- heel bone mineral density · score 0.41
- mean platelet volume · score 0.41
- Romano-Ward syndrome · score 0.39
- monocyte count · score 0.37
- T wave morphology measurement · score 0.37
- mean corpuscular volume · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75052-F1 | alphafold | PREDICTED | 64.60 | — |
Amino-acid sequence (506 residues)
MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT WDESKMLVMQ DPIYRIFYVS HDSQDLKIFS YIARDGASNI FRCNVFKSKK KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA DGQEDGESER NSNSSGDPGR QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL DAVGKEGGSH TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS LLVKQVQELE LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH SPPLGAGLAD FAHPAGSPLG RRDCLVKLEC FRFLPPEDTP PPAQGEALLG GLELIKFRES GIASEYESNT DESEERDSWS QEELPRLLNV LQRQELGDGL DDEIAV
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