Syndecan-3 (SDC3)

About Syndecan-3

Syndecan-3 (SDC3) is a protein from Homo sapiens identified by UniProt accession O75056, 442 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Syndecan-3
UniProt accession	O75056
Gene	SDC3
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

COVID-19 · score 0.54
breast adenocarcinoma · score 0.26
cutaneous melanoma · score 0.24
eosinophil count · score 0.23
thyroid gland adenocarcinoma · score 0.22
lung adenocarcinoma · score 0.22
head and neck squamous cell carcinoma · score 0.17
gastric adenocarcinoma · score 0.13
appendicular lean mass · score 0.13
gut microbiome measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75056-F1	alphafold	PREDICTED	52.74	—

Amino-acid sequence (442 residues)

MKPGPPHRAG AAHGAGAGAG AAAGPGARGL LLPPLLLLLL AGRAAGAQRW RSENFERPVD LEGSGDDDSF PDDELDDLYS GSGSGYFEQE SGIETAMRFS PDVALAVSTT PAVLPTTNIQ PVGTPFEELP SERPTLEPAT SPLVVTEVPE EPSQRATTVS TTMATTAATS TGDPTVATVP ATVATATPST PAAPPFTATT AVIRTTGVRR LLPLPLTTVA TARATTPEAP SPPTTAAVLD TEAPTPRLVS TATSRPRALP RPATTQEPDI PERSTLPLGT TAPGPTEVAQ TPTPETFLTT IRDEPEVPVS GGPSGDFELP EEETTQPDTA NEVVAVGGAA AKASSPPGTL PKGARPGPGL LDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards