About EF-hand calcium-binding domain-containing protein 14
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) is a protein
from Homo sapiens identified by UniProt accession
O75071, 495 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 14 |
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| UniProt accession | O75071 |
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| Gene | EFCAB14 |
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| Organism | Homo sapiens |
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| Length | 495 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.05
- Familial short QT syndrome · score 0.04
- X-linked retinal dysplasia · score 0.04
- gnb5-related intellectual disability-cardiac arrhythmia syndrome · score 0.04
- Romano-Ward syndrome · score 0.04
- Familial progressive cardiac conduction defect · score 0.04
- familial retinal arterial macroaneurysm · score 0.04
- familial atrial fibrillation · score 0.04
- atrial conduction disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75071-F1 | alphafold | PREDICTED | 67.27 | — |
Amino-acid sequence (495 residues)
MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE FGVVGNRSRF AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE DLDALKEKFR TMESNQKSSF QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV WINITEMNKQ ISLLTSAVNH LKANVKSAAD LISLPTTVEG LQKSVASIGN TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG SNQIIPSPSA TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD TVKIQSIKKE DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES FTSKPSALPK FSQFLGDPVE KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG DGRYSFLELR VALGI
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