About Ribitol-5-phosphate transferase FKTN
Ribitol-5-phosphate transferase FKTN (FKTN) is a protein
from Homo sapiens identified by UniProt accession
O75072, 461 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Ribitol-5-phosphate transferase FKTN |
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| UniProt accession | O75072 |
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| Gene | FKTN |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 · score 0.83
- Congenital muscular dystrophy, Fukuyama type · score 0.83
- autosomal recessive limb-girdle muscular dystrophy type 2M · score 0.81
- muscular dystrophy-dystroglycanopathy (congenital without intellectual disability), type B4 · score 0.77
- dilated cardiomyopathy 1X · score 0.74
- muscular dystrophy-dystroglycanopathy, type A · score 0.65
- Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies · score 0.57
- autosomal recessive limb-girdle muscular dystrophy type 2T · score 0.55
- Abnormality of the cardiovascular system · score 0.54
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75072-F1 | alphafold | PREDICTED | 91.97 | — |
Amino-acid sequence (461 residues)
MSRINKNVVL ALLTLTSSAF LLFQLYYYKH YLSTKNGAGL SKSKGSRIGF DSTQWRAVKK FIMLTSNQNV PVFLIDPLIL ELINKNFEQV KNTSHGSTSQ CKFFCVPRDF TAFALQYHLW KNEEGWFRIA ENMGFQCLKI ESKDPRLDGI DSLSGTEIPL HYICKLATHA IHLVVFHERS GNYLWHGHLR LKEHIDRKFV PFRKLQFGRY PGAFDRPELQ QVTVDGLEVL IPKDPMHFVE EVPHSRFIEC RYKEARAFFQ QYLDDNTVEA VAFRKSAKEL LQLAAKTLNK LGVPFWLSSG TCLGWYRQCN IIPYSKDVDL GIFIQDYKSD IILAFQDAGL PLKHKFGKVE DSLELSFQGK DDVKLDVFFF YEETDHMWNG GTQAKTGKKF KYLFPKFTLC WTEFVDMKVH VPCETLEYIE ANYGKTWKIP VKTWDWKRSP PNVQPNGIWP ISEWDEVIQL Y
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