About Transcriptional corepressor CBFA2T3
Transcriptional corepressor CBFA2T3 (CBFA2T3) is a protein
from Homo sapiens identified by UniProt accession
O75081, 653 residues long.
MolForge cross-references it against 0 known binders and
375 disease associations.
Target properties
| Protein name | Transcriptional corepressor CBFA2T3 |
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| UniProt accession | O75081 |
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| Gene | CBFA2T3 |
|---|
| Organism | Homo sapiens |
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| Length | 653 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (375)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.47
- mean platelet volume · score 0.44
- mean corpuscular hemoglobin concentration · score 0.43
- mean reticulocyte volume · score 0.39
- mean corpuscular hemoglobin · score 0.39
- acute myeloid leukemia · score 0.38
- lung carcinoma · score 0.37
- thyroid neoplasm · score 0.37
- breast ductal adenocarcinoma · score 0.37
- lymphoid neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75081-F1 | alphafold | PREDICTED | 60.93 | — |
Amino-acid sequence (653 residues)
MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR
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