About Frizzled-7
Frizzled-7 (FZD7) is a protein
from Homo sapiens identified by UniProt accession
O75084, 574 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Frizzled-7 |
|---|
| UniProt accession | O75084 |
|---|
| Gene | FZD7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 574 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (176)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.40
- heel bone mineral density · score 0.39
- bone quantitative ultrasound measurement · score 0.36
- hair color · score 0.34
- age at first sexual intercourse measurement · score 0.34
- bone density · score 0.33
- smoking status measurement · score 0.30
- attention deficit hyperactivity disorder · score 0.28
- antisocial behaviour measurement · score 0.28
- substance abuse · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75084-F1 | alphafold | PREDICTED | 83.16 | — |
Amino-acid sequence (574 residues)
MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG QVDGDLLSGV CYVGLSSVDA LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVLACYF YEQAFREHWE RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV GITTGFWIWS GKTLQSWRRF YHRLSHSSKG ETAV
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