About LIM domain-binding protein 3
LIM domain-binding protein 3 (LDB3) is a protein
from Homo sapiens identified by UniProt accession
O75112, 727 residues long.
MolForge cross-references it against 0 known binders and
283 disease associations.
Target properties
| Protein name | LIM domain-binding protein 3 |
|---|
| UniProt accession | O75112 |
|---|
| Gene | LDB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 727 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (283)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.77
- Late-onset distal myopathy, Markesbery-Griggs type · score 0.71
- myofibrillar myopathy 4 · score 0.65
- left ventricular noncompaction · score 0.63
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.44
- dilated cardiomyopathy · score 0.43
- myofibrillar myopathy · score 0.42
- Abnormality of the cardiovascular system · score 0.42
- familial isolated dilated cardiomyopathy · score 0.40
- electrocardiography · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75112-F1 | alphafold | PREDICTED | 60.71 | — |
Amino-acid sequence (727 residues)
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD SASPVYQAVI KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSST PIEHAPVCTS QATTPLLPAS AQPPAAASPS AASPPLATAA AHTAIASAST TAPASSPADS PRPQASSYSP AVAASSAPAT HTSYSEGPAA PAPKPRVVTT ASIRPSVYQP VPASTYSPSP GANYSPTPYT PSPAPAYTPS PAPAYTPSPV PTYTPSPAPA YTPSPAPNYN PAPSVAYSGG PAEPASRPPW VTDDSFSQKF APGKSTTSIS KQTLPRGGPA YTPAGPQVPP LARGTVQRAE RFPASSRTPL CGHCNNVIRG PFLVAMGRSW HPEEFTCAYC KTSLADVCFV EEQNNVYCER CYEQFFAPLC AKCNTKIMGE VMHALRQTWH TTCFVCAACK KPFGNSLFHM EDGEPYCEKD YINLFSTKCH GCDFPVEAGD KFIEALGHTW HDTCFICAVC HVNLEGQPFY SKKDRPLCKK HAHTINL
Explore LIM domain-binding protein 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets