About Pentatricopeptide repeat-containing protein 1, mitochondrial
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) is a protein
from Homo sapiens identified by UniProt accession
O75127, 700 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Pentatricopeptide repeat-containing protein 1, mitochondrial |
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| UniProt accession | O75127 |
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| Gene | PTCD1 |
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| Organism | Homo sapiens |
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| Length | 700 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Alzheimer disease · score 0.27
- Parkinson disease · score 0.26
- multiple sclerosis · score 0.26
- lysosomal storage disease · score 0.26
- reticulocyte count · score 0.18
- mean platelet volume · score 0.18
- HbA1c measurement · score 0.18
- leukocyte count · score 0.16
- dehydroepiandrosterone sulphate measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75127-F1 | alphafold | PREDICTED | 68.04 | — |
Amino-acid sequence (700 residues)
MDFVRLARLF ARARPMGLFI LQHLDPCRAR WAGGREGLMR PMWAPFSSSS SQLPLGQERQ ENTGSLGSDP SHSNSTATQE EDEEEEESFG TLSDKYSSRR LFRKSAAQFH NLRFGERRDE QMEPEPKLWR GRRNTPYWYF LQCKHLIKEG KLVEALDLFE RQMLKEERLQ PMESNYTVLI GGCGRVGYLK KAFNLYNQMK KRDLEPSDAT YTALFNVCAE SPWKDSALQS ALKLRQQLQA KNFELNLKTY HALLKMAAKC ADLRMCLDVF KEIIHKGHVV TEETFSFLLM GCIQDKKTGF RYALQVWRLM LSLGLQPSRD SYNLLLVAAR DCGLGDPQVA SELLLKPREE ATVLQPPVSR QRPRRTAQAK AGNLMSAMLH VEALERQLFL EPSQALGPPE PPEARVPGKA QPEVDTKAEP SHTAALTAVA LKPPPVELEV NLLTPGAVPP TVVSFGTVTT PADRLALIGG LEGFLSKMAE HRQQPDIRTL TLLAEVVESG SPAESLLLAL LDEHQVEADL TFFNTLVRKK SKLGDLEGAK ALLPVLAKRG LVPNLQTFCN LAIGCHRPKD GLQLLTDMKK SQVTPNTHIY SALINAAIRK LNYTYLISIL KDMKQNRVPV NEVVIRQLEF AAQYPPTFDR YQGKNTYLEK IDGFRAYYKQ WLTVMPAEET PHPWQKFRTK PQGDQDTGKE ADDGCALGGR
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