Copine-3 (CPNE3)

About Copine-3

Copine-3 (CPNE3) is a protein from Homo sapiens identified by UniProt accession O75131, 537 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Copine-3
UniProt accession	O75131
Gene	CPNE3
Organism	Homo sapiens
Length	537 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
body height · score 0.37
Varicose veins · score 0.31
body mass index · score 0.30
body fat percentage · score 0.29
appendicular lean mass · score 0.26
sitting height measurement · score 0.25
glomerular filtration rate · score 0.22
creatinine measurement · score 0.21
cognitive function measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75131-F1	alphafold	PREDICTED	92.18	—

Amino-acid sequence (537 residues)

MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER IKNCLNPQFS KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC TLGQIVSSKK LTRPLVMKTG RPAGKGSITI SAEEIKDNRV VLFEMEARKL DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT EVVKNNLNPV WRPFKISLNS LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS RSSPVEFECI NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG SNGDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ IPPQWQVSHE FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI INHVARFAAA ATQQQTASQY FVLLIITDGV ITDLDETRQA IVNASRLPMS IIIVGVGGAD FSAMEFLDGD GGSLRSPLGE VAIRDIVQFV PFRQFQNAPK EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards