About ICOS ligand
ICOS ligand (ICOSLG) is a protein
from Homo sapiens identified by UniProt accession
O75144, 302 residues long.
MolForge cross-references it against 0 known binders and
376 disease associations.
Target properties
| Protein name | ICOS ligand |
|---|
| UniProt accession | O75144 |
|---|
| Gene | ICOSLG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 302 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (376)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.36
- eosinophil count · score 0.34
- combined immunodeficiency · score 0.31
- eosinophil percentage of leukocytes · score 0.30
- rheumatoid arthritis · score 0.28
- Combined T and B cell immunodeficiency · score 0.27
- genetic disorder · score 0.27
- glioblastoma multiforme · score 0.20
- eosinophil percentage of granulocytes · score 0.19
- sum of eosinophil and basophil counts · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75144-F1 | alphafold | PREDICTED | 82.58 | — |
Amino-acid sequence (302 residues)
MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD KITENPVSTG EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG HV
Explore ICOS ligand with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets