About TSC22 domain family protein 2
TSC22 domain family protein 2 (TSC22D2) is a protein
from Homo sapiens identified by UniProt accession
O75157, 780 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | TSC22 domain family protein 2 |
|---|
| UniProt accession | O75157 |
|---|
| Gene | TSC22D2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 780 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.32
- neurodegenerative disease · score 0.30
- high density lipoprotein cholesterol measurement · score 0.29
- sex hormone-binding globulin measurement · score 0.29
- PR interval · score 0.28
- BMI-adjusted waist-hip ratio · score 0.28
- triglyceride measurement · score 0.27
- brain measurement · score 0.27
- self reported educational attainment · score 0.25
- mosaic loss of chromosome Y measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75157-F1 | alphafold | PREDICTED | 47.03 | — |
Amino-acid sequence (780 residues)
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD VSRATDYGPE EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA PANGGGVVSA RSVSGALAST LAAAATSAPA PGAPGGPQLA GSSAGPVTAA PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW TCMEYYERDS DSSVLTRSGD CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES GTDSSLTAVS QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA AQQPQQFAYP QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG AAASPATAAT LPVGTGQNAS SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS VPPPQMGGSG PLSAVPGGPH AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ LSSHTPVSRS SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD EDRNPSTAFY QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH LMYAVREEVE VLKEQIKELV ERNSLLEREN ALLKSLSSND QLSQLPTQQA NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
Explore TSC22 domain family protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets