About Phosphatase and actin regulator 2
Phosphatase and actin regulator 2 (PHACTR2) is a protein
from Homo sapiens identified by UniProt accession
O75167, 634 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Phosphatase and actin regulator 2 |
|---|
| UniProt accession | O75167 |
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| Gene | PHACTR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 634 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.33
- vital capacity · score 0.31
- asthma · score 0.26
- multiple sclerosis · score 0.26
- breast adenocarcinoma · score 0.25
- inflammatory bowel disease · score 0.23
- sitting height measurement · score 0.20
- pancreatic adenocarcinoma · score 0.14
- glioblastoma multiforme · score 0.14
- esophageal cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75167-F1 | alphafold | PREDICTED | 60.22 | — |
Amino-acid sequence (634 residues)
MDNAVDGLDK ASIANSDGPT AGSQTPPFKR KGKLSTIGKI FKPWKWRKKK TSDKFRETSA VLERKISTRQ SREELIRRGV LKELPDQDGD VTVNFENSNG HMIPIGEEST REENVVKSEE GNGSVSEKTP PLEEQAEDKK ENTENHSETP AAPALPPSAP PKPRPKPKPK KSPVPPKGAT AGASHKGDEV PPIKKNTKAP GKQAPVPPPK PASRNTTREA AGSSHSKKTT GSKASASPST SSTSSRPKAS KETVSSKAGT VGTTKGKRKT DKQPITSHLS SDTTTSGTSD LKGEPAETRV ESFKLEQTVP GAEEQNTGKF KSMVPPPPVA PAPSPLAPPL PLEDQCITAS DTPVVLVSVG ADLPVSALDP SQLLWAEEPT NRTTLYSGTG LSVNRENAKC FTTKEELGKT VPQLLTPGLM GESSESFSAS EDEGHREYQA NDSDSDGPIL YTDDEDEDED EDGSGESALA SKIRRRDTLA IKLGNRPSKK ELEDKNILQR TSEEERQEIR QQIGTKLVRR LSQRPTTEEL EQRNILKQKN EEEEQEAKME LKRRLSRKLS LRPTVAELQA RRILRFNEYV EVTDSPDYDR RADKPWARLT PADKAAIRKE LNEFKSTEME VHEESRQFTR FHRP
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