About CCR4-NOT transcription complex subunit 3
CCR4-NOT transcription complex subunit 3 (CNOT3) is a protein
from Homo sapiens identified by UniProt accession
O75175, 753 residues long.
MolForge cross-references it against 0 known binders and
195 disease associations.
Target properties
| Protein name | CCR4-NOT transcription complex subunit 3 |
|---|
| UniProt accession | O75175 |
|---|
| Gene | CNOT3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 753 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (195)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with speech delay, autism and dysmorphic facies · score 0.71
- neurodegenerative disease · score 0.54
- genetic disorder · score 0.50
- complex neurodevelopmental disorder · score 0.46
- T-cell acute lymphoblastic leukemia · score 0.37
- nodular melanoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- cutaneous melanoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75175-F1 | alphafold | PREDICTED | 65.43 | — |
Amino-acid sequence (753 residues)
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV RMLETILRML DNDSILVDAI RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA TSPPSHSHME DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP SALGPKASPA PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG GGSGGGGSSS SSNSSAGGGA GKQNGATSYS SVVADSPAEV ALSSSGGNNA SSQALGPPSG PHNPPPSTSK EPSAAAPTGA GGVAPGSGNN SGGPSLLVPL PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL SSLKSMAERA AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH QMPPPHSDTV EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT KYMMWFQRHE EPKTITDEFE QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR DLQ
Explore CCR4-NOT transcription complex subunit 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets