Ankyrin repeat domain-containing protein 17 (ANKRD17)

About Ankyrin repeat domain-containing protein 17

Ankyrin repeat domain-containing protein 17 (ANKRD17) is a protein from Homo sapiens identified by UniProt accession O75179, 2603 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 17
UniProt accession	O75179
Gene	ANKRD17
Organism	Homo sapiens
Length	2603 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
Neurodevelopmental disorder · score 0.37
complex neurodevelopmental disorder · score 0.37
syndromic intellectual disability · score 0.37
lip and oral cavity carcinoma · score 0.34
response to statin · score 0.33
Intellectual disability · score 0.27
total cholesterol measurement · score 0.27
Neurodevelopmental delay · score 0.27
low density lipoprotein cholesterol measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75179-F1	alphafold	PREDICTED	53.37	—

Amino-acid sequence (2603 residues)

MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ GILTETQQGL MVASPAQTLN DTLDDIMAAV SGRASAMSNT PTHSIAASIS QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE SNHDTALTLA CAGGHEELVQ TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA DIEAQSERTK DTPLSLACSG GRQEVVELLL ARGANKEHRN VSDYTPLSLA ASGGYVNIIK ILLNAGAEIN SRTGSKLGIS PLMLAAMNGH TAAVKLLLDM GSDINAQIET NRNTALTLAC FQGRTEVVSL LLDRKANVEH RAKTGLTPLM EAASGGYAEV GRVLLDKGAD VNAPPVPSSR DTALTIAADK GHYKFCELLI GRGAHIDVRN KKGNTPLWLA ANGGHLDVVQ LLVQAGADVD AADNRKITPL MAAFRKGHVK VVRYLVKEVN QFPSDSECMR YIATITDKEM LKKCHLCMES IVQAKDRQAA EANKNASILL EELDLEKLRE ESRRLALAAK REKRKEKRRK KKEEQRRKLE EIEAKNKENF ELQAAQEKEK LKVEDEPEVL TEPPSATTTT TIGISATWTT LAGSHGKRNN TITTTSSKRK NRKNKITPEN VQIIFDDPLP ISYSQPEKVN GESKSSSTSE SGDSDNMRIS SCSDESSNSN SSRKSDNHSP AVVTTTVSSK KQPSVLVTFP KEERKSVSGK ASIKLSETIS EGTSNSLSTC TKSGPSPLSS PNGKLTVASP KRGQKREEGW KEVVRRSKKV SVPSTVISRV IGRGGCNINA IREFTGAHID IDKQKDKTGD RIITIRGGTE STRQATQLIN ALIKDPDKEI DELIPKNRLK SSSANSKIGS SAPTTTAANT SLMGIKMTTV ALSSTSQTAT ALTVPAISSA STHKTIKNPV NNVRPGFPVS LPLAYPPPQF AHALLAAQTF QQIRPPRLPM THFGGTFPPA QSTWGPFPVR PLSPARATNS PKPHMVPRHS NQNSSGSQVN SAGSLTSSPT TTTSSSASTV PGTSTNGSPS SPSVRRQLFV TVVKTSNATT TTVTTTASNN NTAPTNATYP MPTAKEHYPV SSPSSPSPPA QPGGVSRNSP LDCGSASPNK VASSSEQEAG SPPVVETTNT RPPNSSSSSG SSSAHSNQQQ PPGSVSQEPR PPLQQSQVPP PEVRMTVPPL ATSSAPVAVP STAPVTYPMP QTPMGCPQPT PKMETPAIRP PPHGTTAPHK NSASVQNSSV AVLSVNHIKR PHSVPSSVQL PSTLSTQSAC QNSVHPANKP IAPNFSAPLP FGPFSTLFEN SPTSAHAFWG GSVVSSQSTP ESMLSGKSSY LPNSDPLHQS DTSKAPGFRP PLQRPAPSPS GIVNMDSPYG SVTPSSTHLG NFASNISGGQ MYGPGAPLGG APAAANFNRQ HFSPLSLLTP CSSASNDSSA QSVSSGVRAP SPAPSSVPLG SEKPSNVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL STSVGHSGIW SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM ERDSTGIVTP SGTFHQHVPA GYMDFPKVGG MPFSVYGNAM IPPVAPIPDG AGGPIFNGPH AADPSWNSLI KMVSSSTENN GPQTVWTGPW APHMNSVHMN QLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards