About Calcium-transporting ATPase type 2C member 2
Calcium-transporting ATPase type 2C member 2 (ATP2C2) is a protein
from Homo sapiens identified by UniProt accession
O75185, 946 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Calcium-transporting ATPase type 2C member 2 |
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| UniProt accession | O75185 |
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| Gene | ATP2C2 |
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| Organism | Homo sapiens |
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| Length | 946 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (51)
Diseases linked to this target (Open Targets).
- chronic obstructive pulmonary disease · score 0.29
- surfactant protein D measurement · score 0.29
- Cannabis use · score 0.24
- age at onset · score 0.24
- blood protein measurement · score 0.24
- neurodegenerative disease · score 0.22
- glioblastoma multiforme · score 0.14
- breast adenocarcinoma · score 0.10
- triple-negative breast cancer · score 0.09
- anti-chlamydia trachomatis antibody measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75185-F1 | alphafold | PREDICTED | 81.23 | — |
Amino-acid sequence (946 residues)
MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT ALPPKEACKC QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE PVWKKYLDQF KNPLILLLLG SALVSVLTKE YEDAVSIATA VLVVVTVAFI QEYRSEKSLE ELTKLVPPEC NCLREGKLQH LLARELVPGD VVSLSIGDRI PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT TLSNIVFMGT LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG VLRMAKKRVI VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL RAEVSGVGYD GQGTVCLLPS KEVIKEFSNV SVGKLVEAGC VANNAVIRKN AVMGQPTEGA LMALAMKMDL SDIKNSYIRK KEIPFSSEQK WMAVKCSLKT EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC LQEEKRMGSL GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT SPKHKLKIIK ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK EAANMILVDD DFSAIMNAVE EGKGIFYNIK NFVRFQLSTS ISALSLITLS TVFNLPSPLN AMQILWINII MDGPPAQSLG VEPVDKDAFR QPPRSVRDTI LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT MTFTCFVFFD LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV
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