DnaJ homolog subfamily B member 6 (DNAJB6)

About DnaJ homolog subfamily B member 6

DnaJ homolog subfamily B member 6 (DNAJB6) is a protein from Homo sapiens identified by UniProt accession O75190, 326 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	DnaJ homolog subfamily B member 6
UniProt accession	O75190
Gene	DNAJB6
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

Autosomal dominant limb-girdle muscular dystrophy type 1D · score 0.78
autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6) · score 0.75
Autosomal dominant limb-girdle muscular dystrophy · score 0.42
muscular dystrophy, limb-girdle, autosomal dominant · score 0.37
neurodegenerative disease · score 0.36
Abnormality of the musculature · score 0.34
Parkinson disease · score 0.26
Hereditary late-onset Parkinson disease · score 0.26
platelet crit · score 0.25
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75190-F1	alphafold	PREDICTED	62.96	—

Amino-acid sequence (326 residues)

MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF REFFGGRDPF SFDFFEDPFE DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF GGSGMGNFKS ISTSTKMVNG RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE ERMRRGQNAL PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG LKEGGKRKKQ KQREESKKKK STKGNH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards