Peroxisomal membrane protein 11A (PEX11A)

About Peroxisomal membrane protein 11A

Peroxisomal membrane protein 11A (PEX11A) is a protein from Homo sapiens identified by UniProt accession O75192, 247 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Peroxisomal membrane protein 11A
UniProt accession	O75192
Gene	PEX11A
Organism	Homo sapiens
Length	247 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

body height · score 0.16
PHF-tau measurement · score 0.13
serum alanine aminotransferase measurement · score 0.05
aspartate aminotransferase measurement · score 0.05
glycogen storage disease VI · score 0.04
transient infantile hypertriglyceridemia and hepatosteatosis · score 0.04
neonatal intrahepatic cholestasis due to citrin deficiency · score 0.04
hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency · score 0.04
proteasome-associated autoinflammatory syndrome 5 · score 0.04
morbid obesity · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75192-F1	alphafold	PREDICTED	88.19	—

Amino-acid sequence (247 residues)

MDAFTRFTNQ TQGRDRLFRA TQYTCMLLRY LLEPKAGKEK VVMKLKKLES SVSTGRKWFR LGNVVHAIQA TEQSIHATDL VPRLCLTLAN LNRVIYFICD TILWVRSVGL TSGINKEKWR TRAAHHYYYS LLLSLVRDLY EISLQMKRVT CDRAKKEKSA SQDPLWFSVA EEETEWLQSF LLLLFRSLKQ HPPLLLDTVK NLCDILNPLD QLGIYKSNPG IIGLGGLVSS IAGMITVAYP QMKLKTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards