About Gamma-glutamylcyclotransferase
Gamma-glutamylcyclotransferase (GGCT) is a protein
from Homo sapiens identified by UniProt accession
O75223, 188 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Gamma-glutamylcyclotransferase |
|---|
| UniProt accession | O75223 |
|---|
| Gene | GGCT |
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| Organism | Homo sapiens |
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| Length | 188 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (211)
Diseases linked to this target (Open Targets).
- obesity · score 0.39
- cancer · score 0.10
- papillary thyroid carcinoma · score 0.09
- conduction system disorder · score 0.09
- Blackfan-Diamond anemia · score 0.07
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06
- dehydrated hereditary stomatocytosis · score 0.05
- hemoglobin D disease · score 0.05
- Congenital dyserythropoietic anemia type I · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75223-F1 | alphafold | PREDICTED | 93.19 | — |
Amino-acid sequence (188 residues)
MANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII KKGETQTL
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