About Zinc finger protein 780A
Zinc finger protein 780A (ZNF780A) is a protein
from Homo sapiens identified by UniProt accession
O75290, 641 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Zinc finger protein 780A |
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| UniProt accession | O75290 |
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| Gene | ZNF780A |
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| Organism | Homo sapiens |
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| Length | 641 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- nasopharyngeal neoplasm · score 0.12
- small cell lung carcinoma · score 0.09
- attention deficit hyperactivity disorder · score 0.09
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.06
- nicotine metabolite ratio · score 0.06
- Tourette syndrome · score 0.06
- autism · score 0.05
- Phelan-McDermid syndrome · score 0.05
- X-linked non-syndromic intellectual disability · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75290-F1 | alphafold | PREDICTED | 74.61 | — |
Amino-acid sequence (641 residues)
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS KPDVITLLEQ EKEPWMVVRK ETSRRYPDLE LKYGPEKVSP ENDTSEVNLP KQVIKQISTT LGIEAFYFRN DSEYRQFEGL QGYQEGNINQ KMISYEKLPT HTPHASLICN THKPYECKEC GKYFSRSANL IQHQSIHTGE KPFECKECGK AFRLHIQFTR HQKFHTGEKP FECNECGKAF SLLTLLNRHK NIHTGEKLFE CKECGKSFNR SSNLVQHQSI HSGVKPYECK ECGKGFNRGA HLIQHQKIHS NEKPFVCKEC GMAFRYHYQL IEHCQIHTGE KPFECKECGK AFTLLTKLVR HQKIHTGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR SSNLVQHQSI HAGIKPYECK ECGKGFNRGA HLIQHQKIHS NEKPFVCREC EMAFRYHCQL IEHSRIHTGD KPFECQDCGK AFNRGSSLVQ HQSIHTGEKP YECKECGKAF RLYLQLSQHQ KTHTGEKPFE CKECGKFFRR GSNLNQHRSI HTGKKPFECK ECGKAFRLHM HLIRHQKLHT GEKPFECKEC GKAFRLHMQL IRHQKLHTGE KPFECKECGK VFSLPTQLNR HKNIHTGEKA S
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