Growth arrest and DNA damage-inducible protein…

About Growth arrest and DNA damage-inducible protein GADD45 beta

Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) is a protein from Homo sapiens identified by UniProt accession O75293, 160 residues long. MolForge cross-references it against 0 known binders and 256 disease associations.

Target properties

Protein name	Growth arrest and DNA damage-inducible protein GADD45 beta
UniProt accession	O75293
Gene	GADD45B
Organism	Homo sapiens
Length	160 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (256)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
hepatocellular carcinoma · score 0.10
neoplasm · score 0.10
gonorrhea · score 0.09
heel bone mineral density · score 0.09
non-small cell lung carcinoma · score 0.08
hypertension · score 0.08
melanoma · score 0.08
Miyoshi myopathy · score 0.08
colorectal carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75293-F1	alphafold	PREDICTED	89.45	—

Amino-acid sequence (160 residues)

MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)