Reticulon-2 (RTN2)

About Reticulon-2

Reticulon-2 (RTN2) is a protein from Homo sapiens identified by UniProt accession O75298, 545 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Reticulon-2
UniProt accession	O75298
Gene	RTN2
Organism	Homo sapiens
Length	545 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

Autosomal dominant spastic paraplegia type 12 · score 0.72
hereditary spastic paraplegia 12 · score 0.69
Spastic paraplegia · score 0.52
distal hereditary motor neuropathy · score 0.49
Lower limb spasticity · score 0.46
genetic disorder · score 0.19
hereditary spastic paraplegia · score 0.19
autosomal dominant complex spastic paraplegia · score 0.12
PHF-tau measurement · score 0.12
neurofibrillary tangles measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75298-F1	alphafold	PREDICTED	51.20	—

Amino-acid sequence (545 residues)

MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS KAKAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards