About Cadherin-16
Cadherin-16 (CDH16) is a protein
from Homo sapiens identified by UniProt accession
O75309, 829 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Cadherin-16 |
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| UniProt accession | O75309 |
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| Gene | CDH16 |
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| Organism | Homo sapiens |
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| Length | 829 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- alcohol drinking · score 0.29
- high density lipoprotein cholesterol measurement · score 0.29
- diastolic blood pressure · score 0.24
- blood protein measurement · score 0.21
- systolic blood pressure · score 0.19
- renal cell carcinoma · score 0.07
- diet measurement · score 0.04
- neoplasm · score 0.04
- C-reactive protein measurement · score 0.03
- transitional cell carcinoma of kidney · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75309-F1 | alphafold | PREDICTED | 81.78 | — |
Amino-acid sequence (829 residues)
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV
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