About UDP-glucuronosyltransferase 2B11
UDP-glucuronosyltransferase 2B11 (UGT2B11) is a protein
from Homo sapiens identified by UniProt accession
O75310, 529 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 2B11 |
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| UniProt accession | O75310 |
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| Gene | UGT2B11 |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- neuritic plaque measurement · score 0.22
- vitamin D measurement · score 0.19
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.17
- glioblastoma multiforme · score 0.17
- testosterone measurement · score 0.15
- plasma clozapine-to-N-desmethylclozapine ratio measurement · score 0.12
- platelet count · score 0.11
- squamous cell lung carcinoma · score 0.10
- alkaline phosphatase measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75310-F1 | alphafold | PREDICTED | 93.29 | — |
Amino-acid sequence (529 residues)
MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD
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