Ubiquitin carboxyl-terminal hydrolase 12 (USP12)

About Ubiquitin carboxyl-terminal hydrolase 12

Ubiquitin carboxyl-terminal hydrolase 12 (USP12) is a protein from Homo sapiens identified by UniProt accession O75317, 370 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	Ubiquitin carboxyl-terminal hydrolase 12
UniProt accession	O75317
Gene	USP12
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

monocyte count · score 0.46
creatinine measurement · score 0.35
serum alanine aminotransferase measurement · score 0.34
serum gamma-glutamyl transferase measurement · score 0.34
traffic air pollution measurement · score 0.32
urate measurement · score 0.28
glioblastoma multiforme · score 0.23
breast adenocarcinoma · score 0.23
ulcerative colitis · score 0.22
inflammatory bowel disease · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75317-F1	alphafold	PREDICTED	88.39	—

Amino-acid sequence (370 residues)

MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDN ENNNSTPDPT WVHEIFQGTL TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES GYILFYQSRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards