About Hyaluronan mediated motility receptor
Hyaluronan mediated motility receptor (HMMR) is a protein
from Homo sapiens identified by UniProt accession
O75330, 724 residues long.
MolForge cross-references it against 0 known binders and
279 disease associations.
Target properties
| Protein name | Hyaluronan mediated motility receptor |
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| UniProt accession | O75330 |
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| Gene | HMMR |
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| Organism | Homo sapiens |
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| Length | 724 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (279)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.41
- ovarian cancer · score 0.33
- Parkinson disease · score 0.28
- multiple sclerosis · score 0.28
- Alzheimer disease · score 0.28
- neurodegenerative disease · score 0.28
- lysosomal storage disease · score 0.28
- breast adenocarcinoma · score 0.23
- hereditary breast carcinoma · score 0.17
- age-related hearing impairment · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75330-F1 | alphafold | PREDICTED | 74.88 | — |
Amino-acid sequence (724 residues)
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ ESWK
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