T-box transcription factor TBX10 (TBX10)

About T-box transcription factor TBX10

T-box transcription factor TBX10 (TBX10) is a protein from Homo sapiens identified by UniProt accession O75333, 385 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	T-box transcription factor TBX10
UniProt accession	O75333
Gene	TBX10
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.22
waist-hip ratio · score 0.22
apolipoprotein A 1 measurement · score 0.20
ankyloblepharon filiforme adnatum-cleft palate syndrome · score 0.09
urinary metabolite measurement · score 0.09
Ankyloblepharon filiforme adnatum - cleft palate · score 0.08
Ankyloblepharon filiforme - imperforate anus · score 0.07
orofacial cleft 10 · score 0.07
orofacial cleft 5 · score 0.07
orofacial cleft 11 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75333-F1	alphafold	PREDICTED	68.10	—

Amino-acid sequence (385 residues)

MAAFLSAGLG ILAPSETYPL PTTSSGWEPR LGSPFPSGPC TSSTGAQAVA EPTGQGPKNP RVSRVTVQLE MKPLWEEFNQ LGTEMIVTKA GRRMFPPFQV KILGMDSLAD YALLMDFIPL DDKRYRYAFH SSAWLVAGKA DPATPGRVHF HPDSPAKGAQ WMRQIVSFDK LKLTNNLLDD NGHIILNSMH RYQPRFHVVF VDPRKDSERY AQENFKSFIF TETQFTAVTA YQNHRITQLK IASNPFAKGF RESDLDSWPV APRPLLSVPA RSHSSLSPCV LKGATDREKD PNKASASTSK TPAWLHHQLL PPPEVLLAPA TYRPVTYQSL YSGAPSHLGI PRTRPAPYPL PNIRADRDQG GLPLPAGLGL LSPTVVCLGP GQDSQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards