About Arachidonate 12-lipoxygenase, 12R-type
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) is a protein
from Homo sapiens identified by UniProt accession
O75342, 701 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Arachidonate 12-lipoxygenase, 12R-type |
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| UniProt accession | O75342 |
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| Gene | ALOX12B |
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| Organism | Homo sapiens |
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| Length | 701 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (138)
Diseases linked to this target (Open Targets).
- congenital non-bullous ichthyosiform erythroderma · score 0.71
- self-healing collodion baby · score 0.66
- lamellar ichthyosis · score 0.62
- Coats plus syndrome · score 0.45
- leukoencephalopathy with calcifications and cysts · score 0.45
- ichthyosis · score 0.43
- congenital reticular ichthyosiform erythroderma · score 0.40
- autosomal recessive congenital ichthyosis · score 0.37
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75342-F1 | alphafold | PREDICTED | 92.18 | — |
Amino-acid sequence (701 residues)
MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR KIFPGKKSVV SEYVAEHWAE DTFFGYQYLN GVNPGLIRRC TRIPDKFPVT DDMVAPFLGE GTCLQAELEK GNIYLADYRI MEGIPTVELS GRKQHHCAPL CLLHFGPEGK MMPIAIQLSQ TPGPDCPIFL PSDSEWDWLL AKTWVRYAEF YSHEAIAHLL ETHLIAEAFC LALLRNLPMC HPLYKLLIPH TRYTVQINSI GRAVLLNEGG LSAKGMSLGV EGFAGVMVRA LSELTYDSLY LPNDFVERGV QDLPGYYYRD DSLAVWNALE KYVTEIITYY YPSDAAVEGD PELQSWVQEI FKECLLGRES SGFPRCLRTV PELIRYVTIV IYTCSAKHAA VNTGQMEFTA WMPNFPASMR NPPIQTKGLT TLETFMDTLP DVKTTCITLL VLWTLSREPD DRRPLGHFPD IHFVEEAPRR SIEAFRQRLN QISHDIRQRN KCLPIPYYYL DPVLIENSIS I
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